I'm looking for a Senior Scientist/Mass Spec Scientist to join a Global Biotechnology Research organisation based in Oxford.
They are working to create first-in-class biological therapies to address unmet patient needs in oncology as well as infectious and autoimmune diseases.
Responsibilities
Identify protein sequences and post-translational modifications.
Assist in the development of drug substances and products by characterising process intermediates.
Characterise and identify impurities in drug substances and products.
Develop characterisation methods for ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
Design and execute biochemical characterisations, chemical stability assessments, and comparability studies of biologics and drug products.
Contribute to the creation of study protocols and reports.
Independently test and lead lines of investigation.
Propose new experiments based on emerging data and relevant information.
Set work priorities for oneself and team-based projects. Make prioritisation decisions based on team, department, and project goals using direct evidence and experience.
Offer technical guidance on laboratory equipment usage to team members.
Communicate and present research findings at meetings with colleagues, senior management, and partners.
Key Skills
Be able to develop HPLC-based peptide mapping methods and characterise recombinant proteins or antibodies using mass spectrometry.
Conduct glycosylation analysis for recombinant proteins or antibodies.
Coordinate extensive testing of protein biomolecules independently.
Characterise proteins expressed in both microbial and mammalian systems.
Understand post-translational modifications in biological systems.
Work in a bench-based biopharmaceutical laboratory environment.
Have expertise in one or more of the following areas: electrophoresis, chromatography, mass spectrometry.
Confident in developing assays and being able to execute related tasks.
Actively participate and contribute in a diverse team environment.
Propose and implement changes in working practices to improve efficiency, and support teams during transitions.
Present detailed scientific findings and papers to internal and external audiences.
If you're interested in this role, please apply with your updated CV.
For more information please send me a message - [email protected]